Memantine Dosing Guide: What You Need to Know

If you or a loved one has been prescribed memantine for Alzheimer’s, the first question is usually "how much should I take?" The answer isn’t a one‑size‑fits‑all number. Dosage depends on age, kidney function, and how well you handle the drug. Below we break down the usual starting dose, how doctors step it up, and practical tips to stay safe.

Starting Dose and Titration

Most doctors begin with a low dose – typically 5 mg once daily. The goal is to let your body get used to the medication without shocking your system. After a week or two, they usually raise it to 10 mg per day, split into two doses (5 mg in the morning and 5 mg at night). This gradual increase helps reduce side effects like dizziness or headache.

If you tolerate the 10 mg dose well, the next step is often 20 mg per day, again divided into two equal doses. Some people stay on 10 mg because higher amounts cause unwanted nausea or fatigue. Your doctor will decide based on how you feel and any lab results they have.

Important tip: never skip a dose hoping the next one will “catch up.” If you miss a single pill, just take it as soon as you remember unless it’s almost time for your next dose. In that case, skip the missed one – taking two close together can increase side effects.

Maintenance Dose & Tips

The typical maintenance range for most adults is 10–20 mg twice daily (total 20‑40 mg per day). For older patients or those with kidney problems, doctors might keep the dose at the lower end to avoid accumulation. Always let your doctor know if you have kidney disease; they may order blood tests to fine‑tune the amount.

Watch for side effects that are linked to dosing errors. Common issues include constipation, dizziness, or a feeling of restlessness. If any of these get worse after a dose increase, call your prescriber – they might slow down the titration or switch you to an alternative.

Another practical tip: take memantine with food if it upsets your stomach. Some people find splitting tablets with a pill cutter makes swallowing easier and helps keep doses consistent.

Finally, keep a simple log of when you take each dose. A phone alarm or a daily pill box can prevent missed or double‑doses. Consistency is key for memantine to work effectively in slowing cognitive decline.

Remember, the dosage plan is personalized. The numbers above are typical, but your doctor may adjust them based on how you respond. If anything feels off, reach out right away – better safe than sorry when dealing with brain health.